📃 Paper Title: Long-Term Outcomes of Radical Radiation Therapy with Hypoxia Modification with Biomarker Discovery for Stratification: 10-Year Update of the BCON (Bladder Carbogen Nicotinamide) Phase 3 Randomized Trial (ISRCTN45938399)
🧍 Author: Yee Pei Song
🕒 Year: 2021
📚 Journal: International Journal of Radiation Oncology, Biology, Physics
🌎 Country: UK
ㅤContext to the study:
Is there any benefit of radical radiation therapy with hypoxia modification?
ㅤ✅ Take-home message of study:
Radiotherapy (RT) combined with hypoxic sensitisers, carbogen and nicotinamide (CON) had a 30% 10-year overall survival (OS) compared to 24% in the RT alone group.
ㅤ Prospective multicenter randomised trial
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Study participants:
Number included: 303
Hypoxia score and molecular subtype data were available for 150 patients
Inclusion criteria:
High grade non-muscle invasive and muscle invasive bladder cancer
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Key study outcomes:
Greatest benefit from CON in:
Patients with tumour necrosis; 5-year OS, 53% vs. 33%
Patients with high hypoxia gene score; 5-year OS rate of 51% vs. 34%
Patients with basal molecular subtype; 5-year OS rate of 58% vs. 38%
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Study Limitations:
Non-blinded study
Cause specific survival data not available
Biomarker studies were only undertaken in subset of patients
A larger proportion of patients with T1 tumours in the RT + CON group (10 vs. 0), which may have reduced the number of events
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