ㅤTake-home message from Marcus J Drake 2015, published in European Urology:
This was the first long-term study evaluating the efficacy and safety of a combined alpha blocker and antimuscarinic. There was significant improvement in symptoms as measured by the International Prostate Symptom Score as well as urinary frequency over 12 months. The authors report a urinary retention rate of 1.1% that ranged from 6 to 347 days (median 77) after medication was started. Long-term treatment with fixed-dose combination (FDC) Solifenacin and Tamsulosin was well tolerated and efficacious in men with storage and voiding LUTS, with a low incidence of AUR.
ㅤTake-home message from Christopher Chapple 2009, published in European Urology:
Bothersome overactive bladder symptoms like frequency and urgency improve in men treated with tolterodine extended release (ER) for 12 weeks despite continued α-blocker therapy.