📃 Paper Title: Nonantibiotic prevention and management of recurrent urinary tract infection
🧍 Author: Néha Sihra
🕒 Year: 2018
📚 Journal: Nature Reviews Urology
🌎 Country: UK
ㅤContext to the study:
Can you tell me about a review article exploring non-antibiotic management of urinary tract infections?
ㅤ✅ Take-home message of study:
Alternatives to antibiotics for the prevention of recurrent urinary tract infection are attractive options to reduce the risks of antimicrobial resistance.
The most commonly studied nonantibiotic management options for recurrent urinary tract infections are cranberries, probiotics, d-mannose, methenamine hippurate, estrogens, intravesical glycosaminoglycans and immunostimulants.
Studies of novel vaccines targeting the adherence mechanisms of uropathogenic bacteria seem promising, but human trials are required to determine the efficacy of this approach.
Evidence for the nonantibiotic measures is hampered by considerable heterogeneity, and further high-quality trials are needed.
ㅤ Narrative Review
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Study participants:
Not applicable
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Key study outcomes:
This is a narrative review, covering:
Pathogenesis of uncomplicated urinary tract infections
Need for nonantibiotic treatments
Nonantibiotic management options for the prevention and management of recurrent urinary tract infections
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Study Limitations:
Not an original study. Narrative rather than systematic review.
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