📃 Paper Title: Diagnosis of coliform infection in acutely dysuric women
🧍 Author: Walter E. Stamm
🕒 Year: 1982
📚 Journal: The New England Journal of Medicine
🌎 Country: USA
ㅤContext to the study:
Can you tell me about a study that explored the diagnostic criterion for the diagnosis of Coliform infections in women with acute dysuria?
ㅤ✅ Take-home message of study:
Conversely to the traditional diagnostic criterion (≥105 bacteria per millimeter of midstream urine), in female patients presenting with symptoms of UTI:
The best diagnostic criterion is ≥10^2 bacteria per millimeter (sensitivity, 0.95; specificity, 0.85).
The presence of pyuria plus ≥10^2 coliforms per millimeter improved the specificity slightly, but decreased the sensitivity (0.86).
ㅤ Prospective research study
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Study participants:
Number included: 187
**Inclusion criteria: **
Female
LUTS (Dysuria and Frequency)
Exclusion criteria:
History of symptoms > 3 weeks
Pregnant
Fever, flank pain, previous stones
Recent antibiotic use
Diabetes
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Key study outcomes:
Coliforms isolated from bladder urine specimens: 98 out of 187 patients (52.4%)
Coliform counts of the 98 positive patients:
< 10^5 per millimeter (49%).
< 10^4 per millimeter (30%).
The presence of pyuria:
All 98 women with coliforms in urine specimens.
24 of 26 women with no-coliforms isolated in bladder urine.
38 of 63 women with sterile bladder urine.
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Study Limitations:
The lack of a standardised way to collect bladder urine specimens in the cohort (urethral catheterisation & suprapubic aspiration).
Small sample size.
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